The ongoing global pandemic of a severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infections is causing deathsClinical Trials Report, Singapore

Clinical Trials:

Question 1

The ongoing global pandemic of a severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infections is causing deaths daily since its origin. Various researchers and pharmaceutical companies have developed a number of vaccines to fight this coronavirus.

(a) As a clinical trial student, you are required to prepare a report on one (your choice) of the approved in-market vaccines used under the Singapore’s National Vaccination programme. The report should include the following information.

(i) Discuss in detail the vaccine development process involved/followed by the

pharmaceutical company you have selected.

(ii) Analyze the pros and cons of their vaccine. Include in your write-up,

information of the vaccine efficacy and adverse events.

(iii) What are your views on the selected vaccine? Include supporting details to back up your answer.

(b) Write a critical appraisal on any TWO (2) of the following published papers:

(i) McMenamin ME, Nealon J, Lin Y et al.. Vaccine effectiveness of one, two and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong: a population-based observational study. Lancet Infectious Diseases, 2022,

(ii) Daniel RF, Melissa M H, Laith J A-R, et al.. Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression. Lancet, 2022; 399: 924-44.