NBHS1212: Mr. Z, a 38-year-old man was Found to have Hypercholesterolemia: Biochemistry Assignment, OU, Singapore

Objective:

The objective of this assignment is to evaluate the cognitive skills of the learners to understand the fundamental concepts of chemistry, primarily communication ability science in writing throughout complex biological systems.

Scenario:

Mr. Z, a 38-year-old man was found to have hypercholesterolemia. A diet evaluation indicated that he was consuming about 1.6mmol (600mg)/day of cholesterol and his blood plasma cholesterol concentration on two separate occasions was approximately 8.5mmol/L (300mg/dl). The ultracentrifugal analysis revealed that the cholesterol elevation was contained in plasma low-density lipoprotein (LDL).

He was treated with a synthetic cholesterol-free formula diet for 3 months, but the fasting plasma cholesterol level decreased to only 7.7mmol/L (300mg/dL). The medication treatment was successful in lowering the fasting plasma cholesterol concentration to the range of 5.8 to 6.4 mmol/L (220 to 250mg/dl), a value that was considered to be acceptable for this patient.

Requirement:

Describe the etiology of hypercholesterolemia association with blood plasma cholesterol concentration with a synthetic cholesterol-free formula diet for 3 months. Discuss other mechanisms that may help lower Mr. Z’s cholesterol levels to acceptable values of 5.8 – 6.4mmol/L (220 to 250mg/dl).