A2829C Drugs A and B bind to the same type of receptors. These two drugs were studied using organ bath experiments: Drug Action Assignment, RP, Singapore

Section A (30 marks)
Attempt the 3 quizzes in POLITEMall by 8th January 2024.
You will be given 15 minutes for each attempt and only 2 attempts for each
quiz. The higher score will be taken for grade calculation.

Section B (24 marks)
Attempt all the case-based questions below and submit this document with your answers in the SA 2.0 submission folder by 8th January 2024.

1. Drugs A and B bind to the same type of receptors. These two drugs were studied using organ bath experiments, and their graded dose-response curves were plotted as shown in Figure 1.

(a) From the list of drugs given in Table 1, identify ONE drug that could be Drug A, and another ONE drug that could be Drug B. Justify your answers. (6 marks)
Table 1.

(b) With reference to the Drug B that you have chosen from Table 1, state ONE
therapeutic use and ONE side effect of Drug B. Explain your answers. (4 marks)

(c) Drug A binds to Receptors X and Y. With reference to Figure 2, which
Receptors (X or Y) is Drug A more selective for? Explain your answer. (2 marks)