A2829C Compare pharmacokinetics characteristics of Drug K when administered to Jenny and Sally: Drug Action Assignment, RP, Singapore

2. Figure 3 shows the plasma drug concentration versus time curves of 200mg Drug K administered via oral route to two healthy adult volunteers, Jenny and Sally, who are of the same age, body weight, and body type.

a) Compare pharmacokinetics characteristics of Drug K when administered to Jenny and Sally, your answer should include but not be limited to the following:
i. The area under the curve (AUC)
ii. elimination kinetics order
Explain your answers. (7 marks)

b) Provide THREE possible reasons to explain ONE of the Drug K pharmacokinetics differences recognized for Jenny and Sally in part (a). (3 marks)
c) Drug K is metabolized by CYP2D6 to inactive metabolites in the liver. Identify ONE drug in Table 2 that should be avoided when patient is taking Drug K, and explain the clinical consequences if both drugs are taken concurrently. (2 marks)